Septic shock specializing in the diagnosis and treatment of disorders of the lymphatic system9/8/2023 ![]() This cascade of events is responsible for the clinical signs and symptoms of sepsis and progression from sepsis to septic shock. As the primary site of this response, the endothelium not only suffers microvascular injury but also activates the coagulation and complement cascades which further exacerbate vascular injury, leading to capillary leak. ![]() In response to an inciting agent, pro-inflammatory and anti-inflammatory arms of the immune system are activated in concert with the activation of monocytes, macrophages, and neutrophils that interact with the endothelium through pathogen recognition receptors to elaborate cytokines, proteases, kinins, reactive oxygen species, and nitric oxide. ![]() Septic shock, the most severe complication of sepsis, carries a high mortality. Sepsis syndromes span a clinical continuum with variable prognoses.
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